Dozens blocked the front entrance of the Wells Fargo corporate headquarters on Montgomery Street while others surrounded the rest of the building. At least 10 people were arrested for trespassing.
There was a heavy, heavy police presence in the area and at points, lanes were closed near Montgomery, California and Sacramento streets.
It is all part of the ongoing nationwide Occupy Wall Street movement in which people are holding anti-Wall Street rallies, protesting a number of different issues, including foreclosures, unemployment and corporate greed.
The San Francisco version of the movement has had protesters camping out in front of the Federal Reserve Bank of San Francisco at Market and Spear streets.